The song 'I Know You Want Me - Calle Ocho' by Pitbull is about confidence, partying, and enjoying life to the fullest. It portrays a carefree attitude towards love and relationships, with the artist exuding charm and charisma while encouraging others to join in the fun. The lyrics use metaphors like 'Rumba' to symbolize dancing and having a good time, and 'Uno, dos, tres, cuatro' to create a lively and energetic atmosphere throughout the song.